Shute and Lewis first revealed the presence of a cholinergic component of the RAS, composed of two ascending mesopontine tegmental pathways rostrally situated between the mesencephalon and the centrum semiovale ( semioval center ).
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He was also the first to give a comprehensive description of mitral stenosis, as well as other types of heart disease and centrum semiovale, which is sometimes referred to as " Vieussens'centrum ".
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