The genes encoding PLC ( BC-PLC ), and PLCs from " Clostridium bifermentans " and " Listeria monocytogenes " have been isolated and nucleotides sequenced.
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In April, CryoLife recalled seven tissues from six states because a recipient of one of their heart valves developed a clostridium bifermentans infection _ a species common in feces, sewage and soil and associated with gas gangrene.
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Sequence studies have shown the protein to be similar both to alpha toxin from " Clostridium perfringens " and " Clostridium bifermentans ", a phospholipase C involved in haemolysis and cell rupture, and to lecithinase from " Listeria monocytogenes ", which aids cell-to-cell spread by breaking down the 2-membrane vacuoles that surround the bacterium during transfer.
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