Nontraditional dose-response curves are referred to as nonmonotonic dose response curves ."
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It competitively binds to the acetylcholine binding site on mAChRs, causing right-ward shift in the dose response curves for mAChR agonists.
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Even though exercise as carried out in the general population has only modest effects, a dose response curve is found, and very intense exercise can lead to substantial weight loss.
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Alternative definition : ED95 ( when referring to non depolarising muscle relaxants ) is the ED50 from a cumulative log dose response curve where the quantum is a 95 % reduction in twitch height
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In Ames test, where the varying concentrations of the chemical are used in the test, the dose response curve obtained is nearly always linear, suggesting that there is no threshold for mutagenesis.
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An alternative type of model in toxicology is the linear no-threshold model ( LNT ), while hormesis correspond to the existence of opposite effects at low vs . high dose, which usually gives a U-or inverted U-shaped dose response curve.
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One interesting result from the Ames test is that the dose response curve using varying concentrations of chemical is almost always linear, However some proposed that organisms can tolerate low level of mutagens due to protective mechanisms such as DNA repair, and threshold may exist for certain chemical mutagens.
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In Schild regression, the change in the dose ratio, the ratio of the EC 50 of an agonist alone compared to the EC 50 in the presence of a competitive antagonist as determined on a dose response curve used to determine the affinity of an antagonist for its receptor.
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