In 1979, Levin described germinal cell aplasia with focal spermatogenesis where a variable percentage of seminiferous tubules contain germ cells.
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Inactivation of the MTHFR gene in mice has been shown to result in infertility with abnormal testicular histology characterized by the absence of germinal cells and spermatogenesis arrest.
3.
This suggests that differentiation of germinal cells in the ovary and their subsequent arrival in the brood pouch as blastulae is not a continuous process over a breeding season but occurs as one or more cohorts or pulses which stop before the birth rate of young snails reaches its maximum.
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