At Columbia, Muller and his collaborator and longtime friend Edgar Altenburg continued the investigation of lethal mutations.
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This is apparent at the embryonic level, as more evolved animals have more mechanisms preventing lethal mutations of the embryo.
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The litter size of the pollution-exposed mice also tended to be smaller, suggesting that lethal mutations had killed some fetuses.
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The FLT-ITD mutation is one of the most lethal mutations in acute myeloid leukemia ( Chi et al ., 2008 ).
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He also described a lethal mutation in the mouse agouti locus at a time when such a mutation was unheard of.
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Many believe that this ability to evade the accumulation of harmful and possibly lethal mutations produces a substantial advantage for sexually reproducing populations.
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It also has been proposed that activation of an autosomal dominant lethal mutation that survives by mosaicism may be the cause of the lesions.
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If instead only two of those mutants are viable, the rest being lethal mutations, then that sequence is poorly connected and most of its descendants will not reproduce.
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First elaborated by research groups led by Wieschaus and N�sslein-Volhard in the early 1980s, the name was coined to collectively name a series of " Drosophila " embryonic lethal mutations associated with defective exoskeleton formation.
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Also, it was noted by Wilke ( Wilke 2005 ) that the error threshold concept does not apply in portions of the landscape where there are lethal mutations, in which the induced mutation yields zero fitness and prohibits the molecule from reproducing.
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