Wilms tumor is a malignant tumor containing metanephric blastema, stromal and epithelial derivatives.
2.
The system of tissue induction between the ureteric bud and the metanephric blastema is a reciprocal control system.
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The connecting tubule derives from the metanephric blastema, but the rest of the system derives from the ureteric bud.
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In some contexts, the primary division is at the border of kidney and ureter, and in other contexts, the primary division is between derivatives of the metanephric blastema and those of the ureteric bud.
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GDNF, gonadal derived neurotrophic factor, is produced by the metanephric blastema and is essential in binding to the Ret receptor on the ureteric bud, which bifurcates and coalesces as a result to form the renal pelvis, major and minor calyces and collecting ducts.
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