1. Ursodiol is the only FDA approved drug to treat primary biliary cirrhosis . 2. The TNPO3-IRF5 locus is implicated in primary biliary cirrhosis and systemic sclerosis. 3. Overlapping presentation with primary biliary cirrhosis and primary sclerosing cholangitis has been observed. 4. "' Anti-sp100 antibodies "'are found in association with primary biliary cirrhosis . 5. Primary biliary cirrhosis is an autoimmune disease of the liver.6. Modafinil has been shown to improve excessive daytime somnolence and fatigue in primary biliary cirrhosis . 7. Tendon xanthomas are associated with type II hyperlipidemia, chronic biliary tract obstruction, and primary biliary cirrhosis . 8. Primary biliary cirrhosis which often follows chronic active hepatitis is linked to " DRw3 ", DR3, gene.9. It is also envisaged that Hepaconda could be used to treat primary biliary cirrhosis and non-alcoholic steatohepatitis. 10. Primary biliary cirrhosis ( PBC ) is an autoimmune disease characterized by autoantibodies against mitochondrial and nuclear antigens.
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