1. Rheumatoid factor , cryoglobulins, direct antiglobulin test and cold agglutinin titre results can be positive.2. Penicillamine works by reducing numbers of IL-1, decreasing rheumatoid factor , and preventing collagen from cross-linking. 3. Antiphospholipid antibodies, anti-dsDNA, and rheumatoid factor are usually negative, and may help in differentiation from SLE. 4. Types II and III have rheumatoid factor ( RF ) activity and bind to polyclonal immunoglobulins. 5. Rheumatoid factor may be present especially in the group that is likely to develop rheumatoid arthritis.6. "It's relatively unprecedented for drugs or even biologic interventions to change the expression of rheumatoid factor ," 7. In 1939 he discovered the rheumatoid factor . 8. Some patients develop a rheumatoid factor -positive polyarthritis. 9. These might include : rheumatoid factor , antinuclear factor ( ANF ), extractable nuclear antigen, and specific antibodies. 10. Given that ACPA are more specific than rheumatoid factor , they are used to distinguish various causes of arthritis.