11. Physician D . J . Cunningham commented that the skeleton also exhibited marked signs of acromegaly . 12. Melanoma is associated with acromegaly and may have been a final clue to Rachmaninov's diagnosis. 13. Systemic hormonal aberrations such as Cushing s syndrome, galactorrhea and acromegaly usually predate the compressive signs. 14. A duplication event in " GPR101 " is implicated in cases of gigantism and acromegaly . 15. Human adults given growth hormone have suffered from acromegaly ( excess bone growth ) and carpal tunnel syndrome. 16. The apparent pituitary adenoma had at least three additional secondary effects on his medical condition besides causing acromegaly . 17. Acromegaly is a syndrome that results when the anterior pituitary gland produces excess growth hormone ( GH ).18. He continued working as a journalist until after World War I, when the symptoms of acromegaly developed. 19. Rarely, they can be associated with the Birt Hogg Dub?syndrome, acromegaly , and polycystic ovary syndrome. 20. Acromegaly is usually a fatal illness if untreated; 80 % of patients die within 10 years of the diagnosis.