Defects in various enzymes in synthesis of heme can lead to group of disorder called porphyrias, these include acute intermittent porphyria, congenital erythropoetic porphyria, porphyria cutanea tarda, hereditary coproporphyria, variegate porphyria, erythropoietic protoporphyria.
12.
RCOG specifically note current venous thromboembolism, current or past history of breast cancer, inflammatory bowel disease, and acute intermittent porphyria as conditions where the advantages of using emergency contraceptive pills generally outweigh the theoretical or proven risks.
13.
This mechanism is of therapeutic importance : infusion of " heme arginate " or " hematin " and glucose can abort attacks of acute intermittent porphyria in patients with an inborn error of metabolism of this process, by reducing transcription of ALA synthase.
14.
Up to 90 % of the genetic carriers of the more common, dominantly inherited acute hepatic porphyrias ( acute intermittent porphyria, hereditary coproporphyria, variegate porphyria ) have been noted in DNA tests to be latent for classic symptoms and may require DNA or enzyme testing.
15.
Frederic Chopin may have had cystic fibrosis, Vincent van Gogh may have had a metabolic disorder called acute intermittent porphyria, King George III almost certainly had acute intermittent porphyria ( which occasionally turned him mad and into a fit subject for a movie ) and Abraham Lincoln is thought to have had Marfan syndrome, another connective disease that results in great height, puffed out, pigeon breast and enlarged extremities.
16.
Frederic Chopin may have had cystic fibrosis, Vincent van Gogh may have had a metabolic disorder called acute intermittent porphyria, King George III almost certainly had acute intermittent porphyria ( which occasionally turned him mad and into a fit subject for a movie ) and Abraham Lincoln is thought to have had Marfan syndrome, another connective disease that results in great height, puffed out, pigeon breast and enlarged extremities.
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