The alar plate specifically later on becomes the dorsal gray of the spinal cord, and develops into the sensory nuclei of cranial nerves mesencephalic nucleus of V, and main sensory nucleus of V are also developed from this plate.
12.
After sonic hedgehog ( SHH ) signalling from the notochord induces its formation, the floor plate of the incipient neural tube also secretes SHH . After closure, the neural tube forms a basal or floor plate and a roof or alar plate in response to the combined effects of SHH and factors including BMP4 secreted by the roof plate.
13.
In zebrafish, it was shown that the expression of two SHH genes, SHH-a and SHH-b ( formerly described as twhh ) mark the MDO territory, and that SHH signaling is sufficient for the molecular differentiation of both the prethalamus and the thalamus but is not required for their maintenance and SHH signaling from the MDO / alar plate is sufficient for the maturation of prethalamic and thalamic territory while ventral Shh signals are dispensable.
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