11. The aldosterone system is directly targeted by spironolactone, an aldosterone antagonist. 12. Aldosterone synthase is a member of the cytochrome P450 superfamily of enzymes.13. Aldosterone can be inhibited by antialdosteronic drugs such as spironolactone and eplerenone.14. Aldosterone , on the other hand, has differing levels.15. ACTH induces the release of corticosteriods and aldosterone from the adrenal gland. 16. Aldosterone activates sodium channels that result in sodium resorption from the urine.17. This causes the release of aldosterone into the blood. 18. When aldosterone is present, more sodium is reabsorbed and more potassium secreted. 19. In human adrenocortical cells, cinobufagin inhibits the secretion of aldosterone and cortisol. 20. Adrenal hormones such as cortisol and aldosterone also increase.
