11. In normal stem cells, the activity of alkaline phosphatase activity is lowered upon differentiation. 12. Alkaline phosphatase ( ALP ) is an enzyme in the cells lining the Paget's disease.13. The first manifestation of Paget's disease is usually an elevated alkaline phosphatase in the blood. 14. It can also cause elevations in hepatic enzymes such as gamma-glutamyl transferase and alkaline phosphatase . 15. An example of phosphorylating enzyme is found in alkaline phosphatase in its periplasmic region of its membrane. 16. Modest rises in the serum alkaline phosphatase , aspartate transaminase, and amylase may also be seen. 17. The pacient also has abnormal liver test results, such as high GGT and alkaline phosphatase levels. 18. Female homozygotes had a decreased respiratory quotient, increased circulating alkaline phosphatase level and increased leukocyte cell number. 19. Homozygous mutant animals displayed hyperactivity and brain dysmorphology, while males also had decreased circulating alkaline phosphatase levels. 20. Moreover, it can increase alkaline phosphatase activities of mesoblasts, enhance cell proliferation and promote cell adhesion.
