11. Autosomal aneuploidy can also result in disease conditions. 12. Loss of p53 creates genomic instability that most often results in an aneuploidy phenotype. 13. A trisomy is a type of aneuploidy ( an abnormal number of chromosomes ). 14. For other cancers, more work is warranted to identify the causes of aneuploidy . 15. Aneuploidy is a trait of many cancerous tumors.16. Aneuploidy and tumorigenesis can also result from centrosome abnormality, particularly centrosome amplification defects.17. These cells can be tested for chromosome aneuploidy using preimplantation genetic screening ( PGS ). 18. Aneuploidy may be a cause of a random spontaneous as well as recurrent pregnancy loss.19. Thus VHL-loss leads to a weakened checkpoint and subsequently chromosome missegregation and aneuploidy . 20. Failure of centrosome regulation can cause mistakes in chromosome segregation and is associated with aneuploidy .
