11. Finally trauma activates the anterior pituitary gland to release MIF. 12. In elasmobranchs there is an additional, " ventral lobe " beneath the anterior pituitary proper. 13. The pouch eventually loses its connection with the pharynx, giving rise to the anterior pituitary . 14. Adenomas of the anterior pituitary are most often prolactinomas. 15. It is expressed in two cell types, most notably the basophils of the anterior pituitary . 16. The pouch eventually loses its connection with the pharynx giving rise to the anterior pituitary . 17. The anterior pituitary plays a role in stress response. 18. Over time, CRF receptors in the anterior pituitary will become down-regulated, producing depression and anxiety symptoms. 19. Other commonly reported symptoms include anterior pituitary dysfunction, visual field defects, headache / pain, and ophthalmoplegia. 20. At the reception of the signal, corticotrophin-releasing factor ( CRF ) acts on the anterior pituitary .