11. Treatment is usually with either antiplatelet drugs such as aspirin or with anticoagulants such as heparin or warfarin. 12. Therefore, the combination of saw palmetto extract with anticoagulant or antiplatelet drugs should be used with caution. 13. Antiplatelet drug decreases the ability of blood clot to form by interfering with platelet activation process in primary haemostasis.14. Antiplatelet drugs alter the platelet activation at the site of vascular damage crucial to the development of arterial thrombosis.15. With the advent of newer and safer antiplatelet drugs such as clopidogrel and ticagrelor, its use remained limited. 16. It is recommended that pregnant women with thrombocytopenia or a previous diagnosis of ITP should be tested for serum antiplatelet antibodies. 17. Drugs such as antiplatelet agents ( including aspirin ) are usually given to prevent clots, but surgery is usually recommended. 18. "' Ozagrel "'( INN ) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor. 19. Extracts of the plant have significant " in vitro " antioxidant, antiplatelet , and anti-inflammatory activity. 20. The most advantageous aspect is very low access-site bleeding complications even with aggressive use of anticoagulation and antiplatelet therapies.
