11. Biotin supplementation can alleviate and sometimes totally arrest such symptoms.12. The biotin -binding pocket of PCC is hydrophobic and highly conserved. 13. The N1 of biotin is thought to be the active site base. 14. Biotin attachment is required for biotin biosynthesis and utilization of free biotin.15. Biotin attachment is required for biotin biosynthesis and utilization of free biotin. 16. Biotin attachment is required for biotin biosynthesis and utilization of free biotin . 17. Attachment of biotin at the 5 end allows abscript capture. 18. It is also important in freeing biotin from dietary protein-bound biotin. 19. It is also important in freeing biotin from dietary protein-bound biotin . 20. Biotin and retinoic acid increase GCK mRNA transcription as well as GK activity.
