11. ACE inhibitors block ACE, the enzyme that among other actions, degrades bradykinin . 12. Treatment of A431 cells with bradykinin reduces basal and EGF-induced EGFR phosphorylation. 13. Currently, bradykinin inhibitors ( hereditary angioedema. 14. Other less known functions of ACE are degradation of bradykinin and amyloid beta-protein. 15. HMWK is also a precursor of bradykinin ; this vasodilator is released through positive feedback by kallikrein. 16. When mechanisms for the degradation of bradykinin are impaired, the peptide builds up and causes hypotension. 17. A genetic predisposition may exist toward this adverse effect in patients who degrade bradykinin more slowly than average. 18. Moreover, plasmin induces the generation of bradykinin in mice and humans trough high molecular weight kininogen cleavage. 19. In kidney cells, the bradykinin receptor B2 has been shown to interact directly with a protein tyrosine phosphatase. 20. ACh also causes the salivary gland to release kallikrein, an enzyme that converts kininogen to lysyl-bradykinin .
