11. Only 5 10 % of L-DOPA crosses the blood brain barrier . 12. Vinpocetine crosses the blood brain barrier and is taken up by cerebral tissue. 13. By mimicking calcium, lead is able to cross the blood-brain barrier . 14. Ibudilast crosses the blood brain barrier and suppresses glial cell activation. 15. The metalloprotease Mpr1 has been demonstrated to be critical in blood-brain barrier penetration. 16. Partition coefficients quantify the ability of the molecule to cross the blood-brain barrier . 17. Astrocytes have been claimed to be necessary to create the blood brain barrier . 18. Etoxadrol is lipophilic and can readily cross the blood brain barrier . 19. Both MPTP and rotenone are lipophilic and can cross the blood brain barrier . 20. It is capable of crossing the blood-brain barrier and initiating synthesis of TLRs ).