In some Strychnos plants a 9, 10-dimethoxy derivative of strychnine, the alkaloid brucine, is also present.
12.
Since brucine is a large chiral molecule, it has been used as an enantioselective recognition agent using in chiral resolution.
13.
Brucine was first discovered in 1819 by Caventou in the bark of the " Strychnos nux-vomica " tree.
14.
Brucine has also been used in fractional distillation in acetone in order to resolve dihydroxy fatty acids, as well as diarylcarbinols.
15.
Brucine's toxicity arises because glycine is blocked from binding to its receptors, making inhibition of an action potential more difficult.
16.
Brucine is also used in traditional Chinese medicine as an anti-inflammatory and analgesic agent, as well as in some Ayurveda and homeopathy drugs.
17.
One of the most famous cultural references to brucine occurs in " The Count of Monte Cristo ", the novel by French author Alexandre Dumas.
18.
For example, Brucine has an index of 11, is thus perceived as intensely more bitter than quinine, and is detected at a much lower solution threshold.
19.
His apprenticeship apparently complete, Steve shares a celebratory bottle of wine with Bishop, having coated the latter's glass with brucine, a colorless and deadly alkaloid.
20.
It is a major source of the highly poisonous, intensely bitter alkaloids strychnine and brucine, derived from the seeds inside the tree's round, green to orange fruit.
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