11. Carbonic anhydrase is required by osteoclasts for proton production.12. Several forms of carbonic anhydrase occur in nature. 13. This drug can also be used for sleep apnea treatment along with a carbonic anhydrase inhibitor. 14. The enzyme monomer of CS 2 hydrolase displays a typical ?-carbonic anhydrase fold and active site. 15. In living systems an enzyme, carbonic anhydrase , speeds the interconversion of CO 2 and carbonic acid. 16. The enzyme carbonic anhydrase catalyses the reaction between carbon dioxide and water to form carbonic acid. 17. Methazolamide is also a carbonic anhydrase inhibitor. 18. It is expected to have fewer side effects than topiramate because it lacks activity against carbonic anhydrase . 19. The mechanism of action of methocarbamol is currently unknown, but may involve the inhibition of carbonic anhydrase . 20. Rarely, the inhibition of carbonic anhydrase may be strong enough to cause metabolic acidosis of clinical importance.