11. This mechanism ensures that the cells wherein pro-carboxypeptidase A is produced are not themselves digested. 12. For example, many enzymes are metal complexes, like carboxypeptidase , a hydrolytic enzyme important in digestion. 13. Second, a carboxypeptidase removes the Lys / Arg residues leaving Gly as the C-terminal residue. 14. "' Procarboxypeptidase "'is a precursor ( zymogen ) to the pancreatic enzyme carboxypeptidase . 15. Within cells, carboxypeptidase E is present in the secretory granules along with its peptide substrates and products. 16. Classified as a metalloexopeptidase, carboxypeptidase A consists of a single polypeptide chain bound to a zinc ion. 17. Although the tubulin carboxypeptidase has yet to be identified, its activity was first identified in the late 1970s. 18. Thrombomodulin functions as a thrombin-activatable fibrinolysis inhibitor ( TAFI, aka carboxypeptidase B2 ) into its active form. 19. When it is activated by proteolysis at residue Arg92 by the thrombin / thrombomodulin complex, CPB2 exhibits carboxypeptidase activity. 20. For example, a drug that treats high blood pressure, Captopril, was designed based on a carboxypeptidase A inhibitor.
