Although tar has long been considered the carcinogenic agent in cigarettes, the new findings suggest that nicotine and compounds derived from it may also help promote the development and progression of cancer.
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Although nicotine is the predominant addictive chemical in tobacco smoke, it is the other ( approximately 4000 ) chemicals, including carcinogenic agents in the particulate phase, that lead to the well-established adverse health consequences of smoking.
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The "'Cancer Slope Factor "'is used to derive the Risk Specific Dose ( RSD ) ( mg / kg-day ) for direct-acting carcinogenic agents, those that cause chemical changes ( mutations ) in DNA . It is also the default choice for carcinogens when there are insufficient data to demonstrate that the mode of action of the chemical is nonlinear.
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