Intracellular cyclic AMP levels rise and this then activates "'CAP "'( catabolite activator protein ), which is involved in the catabolite repression system, also known as glucose effect.
12.
In particular, his research focused on the phenomenon of catabolite repression, a regulatory system involving interactions of cyclic AMP, the catabolite repressor protein ( CRP ) complex, and the lac operon and other inducible systems in bacteria.
13.
A powerful method of overcoming the catabolite repression in the enzyme biosynthesis is a fed-batch culture in which glucose concentration in the culture liquid is kept low, where growth is restricted, and the enzyme biosynthesis is derepressed.
14.
Although the mechanism behind the environment's involvement in modulating the signals expressing the toxins is not understood, in vitro studies have shown that expression of toxin is strengthened by catabolite repression and stress, e . g . antibiotics.
15.
This was done with " C . difficile " and doses of biotin as small as 0.05nM . Several other early studies have argued against the theory that the production of toxin has anything to deal with stress or catabolite repression of either toxin TcdA or TcdB . Also, many studies say the main reason for the differences among other studies is due to toxin production not occurring with all isolates of " C . difficile ".
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