11. But other strains in Africa and Asia are what is considered chloroquine resistant. 12. Atovaquone-proguanil is an effective alternative in patients unable to tolerate chloroquine . 13. Standard treatment is concurrent treatment with chloroquine and primaquine. 14. The emergence of chloroquine resistance was investigated, but this was not detected. 15. Malarone has applications for treating chloroquine -resistant malaria. 16. But prevention is recommended with chloroquine ( Aralen ) or mefloquine ( Lariam ). 17. Mefloquine was developed when malaria evolved into a form that resisted the drug chloroquine . 18. Most African countries have used chloroquine as their first-line drug since 1970. 19. Examples of such drugs include sulphasalazine, chloroquine , penicillamine, gold and methotrexate. 20. Examples include amodiaquine, chloroquine , and hydroxychloroquine.