11. This facilitates the conversion of O 2 and L-arginine to NO and L-citrulline . 12. Argininosuccinate synthetase and argininosuccinate lyase recycle citrulline , a byproduct of nitric oxide production, into arginine. 13. There is 45.44 % of citrulline of free amino acids ( amino acids in blood ). 14. He found that citrulline acted as a catalyst in the metabolic reactions of urea from ammonia and carbon dioxide. 15. Active site of argininosuccinate synthetase shown with bound citrulline , ATP, and aspartate interacting with select active site residues. 16. The systematic name of this enzyme class is "'L-citrulline N5-carbamoyldihydrolase " '. 17. The advantage of the citrulline -valine ( VC ) linker being used that it is highly stable in plasma. 18. This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine to citrulline residues. 19. In the reaction from arginine to citrulline , one of the terminal nitrogen atoms of the arginine side chain is replaced by an oxygen. 20. This is demonstrated by the fact that, in many cell types, citrulline can substitute for arginine to some degree in supporting NO synthesis.
