11. Males typically have larger clotting factors ( vitamin K, prothrombin and platelets ). 12. Also, the man's severe heart disease likely damaged his liver, which produces blood-clotting factor . 13. There's only a tiny market for cryoprecipitate, a clotting factor . 14. Over two years later all six were producing clotting factor . 15. Because they lack the crucial blood-clotting factor , the patients suffer from dangerous spontaneous bleeding. 16. Single-donor plasma is efficacious in the treatment of mild deficiencies of stable clotting factors . 17. Kogenate FS is the newest blood-clotting factor on the market. 18. Because they lack the crucial blood clotting factor , the patients suffer from dangerous spontaneous bleeding. 19. This consumptive coagulopathy also uses up clotting factors , such as fibrinogen which may worsen bleeding. 20. Anti-coagulated blood yields plasma containing fibrinogen and clotting factors .