In humans, 3 H-NIS is used to measure uptake sites in the locus coeruleus ( LC ).
12.
Eventually the neurons in the locus coeruleus enter a refractory period, due to the auto-inhibitory effect of norepinephrine.
13.
Furthermore, overactivity of noradrenergic neurones arising from the locus coeruleus may produce excessive excitation in the brain areas implicated in GAD.
14.
In 1809, he was the first to describe the white fibre tract now called the arcuate fasciculus and the locus coeruleus.
15.
For example, noradrenergic inputs arising from the locus coeruleus have important regulatory effects upon corticotropin-releasing hormone ( CRH ) levels.
16.
Upregulation of the same pathway in the locus coeruleus is also a mechanism responsible for certain aspects of opioid-induced physical dependence.
17.
The therapeutic benefits are due to noradrenergic effects at the locus coeruleus and the prefrontal cortex and dopaminergic effects at the nucleus accumbens.
18.
These neurons are located in the locus coeruleus, dorsal and median raphe nuclei, ventral periaqueductal grey matter, and tuberomammillary nucleus.
19.
So far, a variant of this approach has been applied to map the projection patterns single locus coeruleus neurons at the mesoscale.
20.
Decreased sensitivity of regulatory a2 adrenergic receptors as well as increased cell counts in the locus coeruleus indicated increased noradrenergic activity in manic patients.
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