In the process of binding, decamethonium actually activates ( depolarizes ) the motor endplate-but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release.
12.
One of the outstanding recent contributions to pharmacology and therapeutics is his discovery, with Zaimis, of the actions of the methonium compounds-decamethonium a potent neuromuscular, and hexamethonium a potent ganglion blocking substance.
13.
In the 1950s and 1960s, the present-day concept of a neuromuscular blocking agent with a rapid onset and an ultra-short duration of action had not taken root : researchers and clinicians were still on the quest for potent but non-depolarizing replacements devoid of the histamine release and the dreaded " recurarizing " effects seen with tubocurarine and, more importantly, the absence of a depolarizing mechanism of action as seen with succinylcholine and decamethonium.
14.
From the 1950s through to the 1970s, the present-day concept of a neuromuscular blocking agent with a rapid onset and an ultra-short duration of action had not taken root : researchers and clinicians were still on the quest for potent but non-depolarizing replacements devoid of the histamine release and the dreaded " recurarizing " effects seen with tubocurarine and, more importantly, the absence of a depolarizing mechanism of action as seen with succinylcholine and decamethonium.
How to say decamethonium in Hindi and what is the meaning of decamethonium in Hindi? decamethonium Hindi meaning, translation, pronunciation, synonyms and example sentences are provided by Hindlish.com.
