11. Types of hyperviscosity syndromes vary by pathology; including deformability of red blood cells, often evident in sickle cell anemia. 12. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. 13. Erythrocytes / RBC may also be tested for related membrane properties aside from fragility, including erythrocyte deformability and cell morphology. 14. With very low shear rates, the viscoelastic property of blood is dominated by the aggregation and cell deformability is relatively insignificant. 15. Another beneficial consequence of strong bilayer deformability is the increased affinity of a " Transfersome " to bind and retain water. 16. Erythrocyte deformability has also been demonstrated to be impaired in diabetes, peripheral vascular diseases, sepsis and a variety of other diseases. 17. Because of the link between deformability and sickled cells, deformability can be used to evaluate the amount of sickled cells in the blood. 18. Because of the link between deformability and sickled cells, deformability can be used to evaluate the amount of sickled cells in the blood. 19. Thus for meaningful " apples-to-apples " comparisons involving cell deformability , it is important to utilize the same qualitative approach. 20. "Ektacytometry " based on laser diffraction analysis is a commonly preferred ( and a fairly direct ) method for measuring deformability .
