11. These neurons quickly lose ATP and become depolarized , which releases glutamate. 12. In unhealthy mitochondria, the inner mitochondrial membrane becomes depolarized . 13. The grayanotoxin prevents inactivation, leaving excitable cells depolarized . 14. Depending on the movement, the hair cell can either hyperpolarize or depolarize . 15. If the postsynaptic cell is sufficiently depolarized , an action potential will occur. 16. The same problem exists with the depolarizing NMB succinylcholine. 17. When acetylcholine binds to an already depolarized receptor, it cannot cause further depolarization. 18. Glutamate can depolarize some neurons and hyperpolarize others. 19. The general scheme is that an action potential arrives to depolarize the cell membrane. 20. In this sense, tubocurarine is the prototypical adjunctive neuromuscular non-depolarizing agent.