This structure features an adoral zone of membranelles ( AZM ) partly encircling a wide buccal cavity ( mouth ), which opens into the cytopharyngeal pouch where digestive vacuoles are formed before they travel down a distinctive long, bent tube into the body of the cell.
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Chloroquine-resistant cells efflux chloroquine at 40 times the rate of chloroquine-sensitive cells; the related mutations trace back to transmembrane proteins of the digestive vacuole, including sets of critical mutations in the " P . falciparum " chloroquine resistance transporter ( " PfCRT " ) gene.
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