While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong, although it is presumed to be similarly effective.
12.
Ovine polyclonal anti-digitoxin Fab fragment antibody ( DigiTAb; Therapeutic Antibodies Inc . ) can be used to treat " T . peruviana " poisoning, but for many countries the cost is prohibitive.
13.
Mairanovsky and his colleagues tested a number of deadly poisons on prisoners from the Gulags ( " enemies of the people " ), including mustard gas, ricin, digitoxin, curare, cyanide, and many others.
14.
The foxglove shrub shouldn't be used to cook over, either, for it contains the potent digitoxin, which can cause drooling, abnormal heart rate, cardiac arrhythmias, weakness, collapse, dilated pupils, tremors, seizures, and even death.
15.
However, digitoxin, digoxin and several other cardiac glycosides, such as ouabain, are known to have steep dose-response curves, i . e ., minute increases in the dosage of these drugs can make the difference between an ineffective dose and a fatal one.
16.
In patients with decreased kidney function the half-life is considerably longer, along with decrease in Vd, calling for a reduction in dose or a switch to a different glycoside, such as digitoxin ( not available in the United States ), which has a much longer elimination half-life of around seven days and is eliminated by the liver.
17.
Bauersachs is chair of two clinical trials funded by the German Ministry of Research and Education ( BMBF ) in patients with heart failure : the study investigating the efficacy of Bromocriptine on left ventricular function in women with peripartal cardiomyopathy ( PPCM ) and the large endpoint trial DIGIT-HF ( DIGitoxin to Improve ouTcomes in patients with advanced chronic systolic Heart Failure; EudraCT No : 2013-005326-38 ).
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