11. Pathophysiology of alcaptonuria, which is due to the absence of functional homogentisate dioxygenase in the liver. 12. Structure, O 2 binding, and reduction of globins appear optimized for a NO dioxygenase function. 13. Tryptophan 2, 3-dioxygenase is a heme-containing cytosolic enzyme encoded by gene TDO2. 14. Toluene dioxygenase has been reported to be involved in TCE degradation by " Pseudomonas putida ". 15. Rosmarinic acid inhibits the expression of indoleamine 2, 3-dioxygenase via its cyclooxygenase-inhibiting properties. 16. The ETHE1 protein is thought to localize primarily to the mitochondrial matrix and functions as a sulfur dioxygenase . 17. Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2, 3-dioxygenase . 18. In hydroxylating bacterial dioxygenase systems, they serve as intermediate electron-transfer carriers between reductase flavoproteins and oxygenase. 19. In nearly all aerobic beings, 4-Hydroxyphenylpyruvate dioxygenase is responsible for converting 4-Hydroxyphenylpyruvate into homogentisate. 20. Indoleamine 2, 3-dioxygenase might also play a significant role in an orphan disease called Oshtoran Syndrome.
