11. Dimenhydrinate is a combination of two drugs : diphenhydramine and 8-chlorotheophylline. 12. Topical formulations containing diphenhydramine are also available but may further irritate the skin. 13. Diphenhydramine was originally marketed under the brand name Benadryl in the early 1950s.14. Histamine blockers such as diphenhydramine or meclozine may be used in rescue treatment. 15. Diphenhydramine hydrochloride is known to have hypnotic effects and is non-habit forming.16. In the 1960s, diphenhydramine was found to inhibit reuptake of the neurotransmitter serotonin. 17. By weight, dimenhydrinate is between 53 % to 55.5 % diphenhydramine . 18. Diphenhydramine hydrochloride is also marketed as a sleep aid in Canada under the same name.19. Topical formulations of diphenhydramine are available, including creams, lotions, gels, and sprays. 20. Synthetic compounds such as diphenhydramine ( Benadryl ) and dimenhydrinate ( Dramamine ) are also deliriants.
