Bendroflumethiazide is a thiazide diuretic which works by inhibiting sodium reabsorption at the beginning of the distal convoluted tubule ( DCT ).
12.
It is very probable that the renal tubular cells of the distal convoluted tubules are themselves sensitive to the pH of the plasma.
13.
The salt wasting tubulopathy of EAST syndrome most closely resembles that of Gitelman syndrome which is the most common syndrome affecting the distal convoluted tubule.
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Drugs are excreted from the kidney by proximal and distal convoluted tubules non-ionised acids and weak bases are reabsorbed both actively and passively.
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Specifically, the LGR5 + ve stem cells contribute into the formation of the thick ascending limb of Henle s loop and the distal convoluted tubule.
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The KCNJ10 gene is associated with a K + channel in the distal convoluted tubule and the connecting tubule, two specific regions of the kidneys.
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Mercurial diuretics cause diuresis by reducing the reabsorption sodium in the ascending loop of Henle, thus causing more water being delivered to the distal convoluted tubule.
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Macula densa cells are located in the distal convoluted tubule, and stimulate juxtaglomerular cells to release renin when they detect a drop in sodium concentration in tubular fluid.
19.
Close to the loop of Henle and in the distal convoluted tubule of the nephron where much glucose has been reabsorbed into the bloodstream, SGLT1 transporters are found.
20.
Extraglomerular mesangial cells are part of the juxtaglomerular apparatus, along with the macula densa cells of the distal convoluted tubule and the juxtaglomerular cells of the afferent arteriole.
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