HU-331 inhibits DNA topoisomerase II even at nanomolar concentrations, but has shown a negligible effect on the action of DNA topoisomerase I . The cannabinoid quinone HU-331 is a very specific neoplastic activity while maintaining low toxicity at therapeutic doses.
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The general modes of action found in mammalian cells are inhibition of protein kinases, inhibition of eukaryotic DNA topoisomerase, and intercalative binding to DNA . The number of protein kinases thought to exist in the human genome exceeds six hundred, making a nanomolar inhibitor such as STA extremely useful for both treatment of various diseases and study of protein kinases in a variety of functions.
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