GAB2 is a large multi-site docking protein ( LMD ) of about 100kD that has a folded N-terminal domain attached to an extended, disordered C-terminal tail rich in short linear motifs.
12.
This pathway begins with the Trk receptor complex-recruitment of a second adaptor protein called growth factor-receptor bound protein-2 ( Grb2 ) along with a docking protein called Grb2-associated Binder-1 ( GAB1 ).
13.
BCAR1 is a ubiquitously expressed adaptor molecule originally identified as the major substrate of v-Src and Cas family of adaptor proteins and can act as a docking protein for several signalling partners.
14.
These proteins are scaffolding / docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein.
15.
The hybrid gene would have produced on the surface of the Spanish flu virus a docking protein that resembled human influenza at its roots, but a pig variant at the top where it grabs onto a target cell.
16.
It may be a critical substrate for p210 ( bcr / abl ), a chimeric protein whose presence is associated with CML . Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs.
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