11. After the fusion of the late endosome with the lysosome, lysosomal sialidases remove sialic acid residues. 12. The cargo proteins are then trafficked to the lysosome via the late endosome independently of the IGF2Rs. 13. Once formed, the endosome combines with a structure known as a multivesicular body ( MVB ). 14. Instead, it transforms into a reticulate body ( RB ) and begins to replicate within the endosome . 15. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. 16. Secondly, acidification of the endosome triggers the formation of a pore through which the GTD is translocated. 17. Receptor binding is the first step required for entry into the cell via endocytosis in an acidic endosome . 18. It is localized to the endosomal compartment of the cell with the LRR region facing into the endosome . 19. VP1 has a conserved phospholipase A2 domain which is used by the viron to escape from the endosome . 20. The virus attach to the cell surface via specific receptors and are taken up by an endosome being formed.
