Hanania had to answer two questions : Could he put the MDR-1 gene into the bone marrow of mice and have that bone marrow engraft successfully in animals?
12.
Flt1 + / Flt4 + CPCs derived from iPSCs were shown to engraft into the adult myocardium and robustly differentiate into cardiomyocytes with phenotypic and electrophysiologic characteristics of adult cardiomyocytes.
13.
But the cells, although they look like the real thing, fail to engraft correctly in the bone marrow, as if something had gone awry with their maturation process.
14.
Treatment with a humanized mAb specific for ROR1 ( UC-961 ) could inhibit the capacity of ovarian cancer cells to migrate, form spheroids, or engraft immune-deficient mice.
15.
A few years later, he tested the ability to culture genetically modified CAR-Ts in humans, discovering the cells could engraft and persist in patients with HIV / AIDS for years.
16.
To engraft upon the Social Security system a concept of ` accrued property rights'would deprive it of the flexibility and boldness in adjustment to ever-changing conditions which it demands ."
17.
But the blood-forming cells have not yet been made to engraft properly, as if the test-tube version of the mouse blood-forming cells lacks some necessary ability or signal.
18.
However, the dosing is still high enough that the ultimate result is the destruction of both the patient's bone marrow ( allowing donor marrow to engraft ) and any residual cancer cells.
19.
Baboons have a natural resistance to HIV . So if one could get a baboon immune system to engraft temporarily into a human, the question is : Might it help that human being get rid of the virus?
20.
Conditioning regimens are used to suppress the recipient's immune system in order to allow a transplant to engraft . Cyclophosphamide is a common cytotoxic drug used in this manner, and is often used in conjunction with total body irradiation.
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