That long-lasting action was most likely due to slow dissociation of the enzyme-inhibitor complex and an active oxide metabolite that undergoes enterohepatic circulation.
12.
He published fundamental work on the enterohepatic circulation of bile acids and how disturbances in ileal function such as those found in Crohn's disease can produce chronic diarrhea.
13.
All four of these bile acids can be taken back up into the blood stream, return to the liver, and be re-secreted in a process known as enterohepatic circulation.
14.
Owing to the extremely efficient enterohepatic circulation of B 12, the liver can store 3 to 5 years worth of vitamin B 12; therefore, nutritional deficiency of this vitamin is rare.
15.
A trace ( ~ 1 % ) of the urobilinogen is reabsorbed into the enterohepatic circulation to be re-excreted in the bile : some of this is instead processed by the kidneys, coloring the urine yellow.
16.
Aramchol was initially intended to combine a cholesterol solubilising moiety ( a saturated fatty acid ) with a bile acid ( cholic acid ) acting as a vehicle to enable secretion into bile and entry into the enterohepatic circulation to solubilise bile stones.
17.
Benoxaprofen has a rather long half life in man ( t 1 / 2 = 20-30 h ), undergoes biliary excretion and enterohepatic circulation and is also known to have a slow plasma clearance ( CL p = 4.5 ml / min ).
18.
In September 1994, Jefferson first articulated the Hologenome Theory of Evolution, at a presentation at Cold Spring Harbor Laboratory, at a Symposium " A Decade of PCR " This theory was developed from his molecular and genetic work on glucuronide metabolism by vertebrate-associated microbes, including the role of glucuronidases, sulfatases and other enzymes in modulating and effecting enterohepatic circulation of steroid hormones.
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