However, EEs and CEEs differ in the sources of their contents and in the percentages of their constituents; CEEs consist of approximately 53 % sodium estrone sulfate and 25 % sodium equilin sulfate, while EEs contain approximately 80 % sodium estrone sulfate and 11 % sodium equilin sulfate.
12.
The oral ingestion of 10 mg Premarin, which contains about 4.5 mg sodium estrone sulfate and 2.5 mg sodium equilin sulfate, produces maximal plasma concentrations of estrone and equilin of 1400 pg / mL and 560 pg / mL within 3 and 5 hours, respectively.
13.
The oral ingestion of 10 mg Premarin, which contains about 4.5 mg sodium estrone sulfate and 2.5 mg sodium equilin sulfate, produces maximal plasma concentrations of estrone and equilin of 1400 pg / mL and 560 pg / mL within 3 and 5 hours, respectively.
14.
Conjugated equine estrogens ( CEEs ), such as Premarin, a commonly prescribed estrogenic drug produced from the urine of pregnant mares, include the natural steroidal estrogens equilin and equilenin, as well as, especially, estrone sulfate ( which itself is inactive and becomes active upon conversion into estrone ).
15.
The review also determined that two estrogens estrone sulfate and equilin sulfate were primarily responsible for the activity of Premarin, and it laid the groundwork for Abbreviated New Drug Application ( ANDA ) submissions of generic versions . and 1986 the FDA announced in the Federal Register that Premarin was effective for preventing osteoporosis.
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