11. CTA was the first estrogenic compound of the triphenylethylene series to be introduced. 12. Osaterone acetate has virtually no estrogenic or androgenic activity. 13. It has estrogenic activity and hence is a phytoestrogen. 14. Accelerated sexual development is plausible in individuals exposed to high concentration of estrogenic substances. 15. Unlike some other organic sunscreen actives, it shows no estrogenic effects in vitro. 16. Others possess estrogenic or endocrine disrupting activity. 17. Animal experiments have shown that parabens have a weak estrogenic activity, acting as xenoestrogens. 18. 4-Androstenediol is very weakly estrogenic . 19. Noretynodrel, unlike most progestins but similarly to etynodiol diacetate, has some estrogenic activity. 20. Black cohosh has been shown to have no estrogenic effect in vivo or in vitro.
