The renal lesion associated with malignant hypertension consists of fibrinoid necrosis of the afferent arterioles, sometimes extending into the glomerulus, and may result in focal necrosis of the glomerular tuft.
12.
The response is characterized by an inflammatory infiltrate of mostly macrophages and natural killer cells ( with small numbers of T cells ), intravascular thrombosis, and fibrinoid necrosis of vessel walls.
13.
Common sites undergoing fibrinoid necrosis are, SLE, Aschoff bodies seen in rheumatic heart disease, Arthus reaction, serum sickness, polyarteritis nodosa, poststreptococcal glomerulonephritis, hyperacutely rejected grafts, malignant hypertension ( > 200 / 130 mm Hg ).
14.
However, the term " histiocyte " has been used for multiple purposes in the past, and some cells called " histocytes " do not appear to derive from monocytic-macrophage lines . ( The term Histiocyte can also simply refer to a cell from monocyte origin outside the blood system, such as in a tissue ( as in rheumatoid arthritis as palisading histiocytes surrounding fibrinoid necrosis of rheumatoid nodules ).
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