11. Also, insulin resistance often is associated with a hypercoagulable state ( impaired fibrinolysis ) and increased inflammatory cytokine levels. 12. The circulating enzyme plasmin, the main enzyme of fibrinolysis , cleaves the fibrin gel in a number of places. 13. Plasminogen activator inhibitor-1, an inhibitor of fibrinolysis , is present in higher levels in people with obesity. 14. Thrombomodulin functions as a thrombin-activatable fibrinolysis inhibitor ( TAFI, aka carboxypeptidase B2 ) into its active form. 15. Tranexamic acid and aminocaproic acid inhibit fibrinolysis , and lead to a " de facto " reduced bleeding rate. 16. In DIC, the processes of coagulation and fibrinolysis are dysregulated, and the result is widespread clotting with resultant bleeding. 17. Antifibrinolytics, such as aminocaproic acid ( ?-aminocaproic acid ) and tranexamic acid are used as inhibitors of fibrinolysis . 18. Presumably, lower PAI levels would lead to less suppression of fibrinolysis and conversely a more rapid degradation of the fibrin. 19. In vitro studies confirmed the fibrinolysis inhibition capacity of CU-2010 when present at concentrations between 100 to 1000 nM. 20. Any blood clot forms due to an imbalance between coagulation ( the formation of the insoluble blood protein fibrin ) and fibrinolysis .
