There are three layers to the cerebellar cortex; from outer to inner layer, these are the molecular, Purkinje, and granular layers.
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The second and third layers, or the External Granular layer and External Pyramidal layer respectively, are formed around mouse E13.5 to E16.
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The main problem with this definition is that it works well only in primates but not in nonprimates, as the latter lack a granular layer IV.
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The axon dips through the granular layer, into the white matter, before going up to terminate on basket or stellate cells in the molecular layer.
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Axons from the pyramidal cells ( in EC layer II ) perforate the subiculum to project mainly to the granular layer in the dentate gyrus ( first synaptic connection ).
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At the bottom lies the thick granular layer, densely packed with granule cells, along with interneurons, mainly Golgi cells but also including Lugaro cells and unipolar brush cells.
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The premotor cortex can be distinguished from Brodmann area 46 of the prefrontal cortex, just anterior to it, by the presence of a fully formed granular layer IV in area 46.
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Sometimes the Lugaro cell axon will also terminate on Golgi cells in the granular layer without going on up again to the molecular layer, so that the Golgi cells are the target.
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"The most inconstant or variable layers are Meynert's two so-called granular layers, layers II and IV of the basic pattern ( the outer and inner granular layers ).
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"The most inconstant or variable layers are Meynert's two so-called granular layers, layers II and IV of the basic pattern ( the outer and inner granular layers ).
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