11. The deposited fibroblastic connective tissue matures by secreting ECM into the extracellular space, forming granulation tissue ( see below ). 12. Granulation tissue and new blood vessels form, and fragments of necrotic bone ( sequestra ) are separated from vital bone.13. They form a loose aggregate of cells, interspersed with small blood vessels, known as " granulation tissue ". 14. In a rat model of free-radical scavenging property, HA has been shown to reduce damage to the granulation tissue . 15. An excess of granulation tissue ( " caro luxurians " ) is informally referred to as " proud flesh ." 16. Although inflammation is an integral part of granulation tissue formation, for normal tissue repair to proceed, inflammation needs to be moderated. 17. In chronic angular cheilitis, there may be suppuration ( pus formation ), exfoliation ( scaling ) and formation of granulation tissue . 18. If granulation tissue grows over the injured site, it can cause stenosis of the airway, after a week to a month. 19. When a cholesteatoma or granulation tissue is present in the middle ear, the degree of hearing loss and ossicular destruction is even greater. 20. Angiogenesis is a normal and vital process in growth and development, as well as in wound healing and in the formation of granulation tissue .
