11. This paper attempted to reveal their components and the presence of sialic acid in the amorphous ground substance . 12. However, if the ground substance is chemically imbalanced, the energy resonating through the body loses coherence. 13. Ground substance is primarily composed of water, glycosaminoglycans ( most notably hyaluronan ), proteoglycans, and glycoproteins.14. It contains fine bundles of fibrous connective tissue, primarily collagen, embedded in a matrix of ground substance . 15. In fact, advances in our understanding of the chemical nature of ground substance remained largely neglected for a generation. 16. Connective tissue diseases are caused by a complex array of autoimmune responses that target or affect collagen or ground substance . 17. Fibroblasts then deposit ground substance into the wound bed, and later collagen, which they can adhere to for migration. 18. Whereas mantle dentin forms from the preexisting ground substance of the dental papilla, primary dentin forms through a different process. 19. Fibroblasts secrete the precursors of all the components of the extracellular matrix, primarily the ground substance and a variety of fibers. 20. This system is built on the ground substance , a complex connective tissue between all the cells, often also called the extra-cellular matrix.
