This mechanism is of therapeutic importance : infusion of " heme arginate " or " hematin " and glucose can abort attacks of acute intermittent porphyria in patients with an inborn error of metabolism of this process, by reducing transcription of ALA synthase.
12.
Marketed as "'Halfan "', halofantrine is never used to prevent malaria and its mode of action is unknown, although a crystallographic study showed that it binds to hematin " in vitro ", suggesting a possible mechanism of action.
13.
Later, in 1891, T . Carbone and W . H . Brown ( 1911 ) published papers linking the degradation of hemoglobin with the production of pigment, describing the malaria pigment as a form of hematin and disproving the widely held idea that it is related to melanin.
14.
Any sign of low blood sodium ( hyponatremia ) or weakness should be treated with the addition of hematin, heme arginate, or even tin mesoporphyrin, as these are signs of impending syndrome of inappropriate antidiuretic hormone ( SIADH ) or peripheral nervous system involvement that may be localized or severe, progressing to bulbar paresis and respiratory paralysis.
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