11. They are granulocytes that develop during hematopoiesis in the bone marrow before migrating into blood. 12. MHC crosslinking also activates a signaling pathway that suppresses hematopoiesis and upregulates Fas-mediated apoptosis. 13. Another complication of extramedullary hematopoiesis is poikilocytosis, or the presence of abnormally shaped red blood cells. 14. Microscopically, lymph nodes also contain foci of hematopoiesis , but these are insufficient to cause enlargement. 15. LNK functions as a regulator in signaling pathways relating to hematopoiesis , inflammation, and cell migration. 16. It is a key regulator of multiple events in hematopoiesis , most notably the stimulation of megakaryocyte maturation. 17. For example, both SDS and 5q-syndrome lead to impaired hematopoiesis and a predisposition to leukemia. 18. The bone marrow stem cells give rise to cells of all hematopoietic lineages, through the process of hematopoiesis . 19. There may be evidence of extramedullary hematopoiesis ( marrow elements can be found in the spleen, liver ). 20. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network.
